Protein Details: Potassium voltage-gated channel protein shk-1

Protein ID

ICDB_Pro_1251

Protein Name

Potassium voltage-gated channel protein shk-1

Gene Name

shk-1; ZK1321.2

Organism

Caenorhabditis elegans

Length

536 amino acids

AlphaFoldDB

AF-Q8I4B0-F1-model_v4.pdb

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Has an important role in repolarization and in regulating the pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d

Sequence

MRFGGQRRCIESSDDNDSIDSMSIQQKNKEKEEWKWAQSLARRLEQVLNVHPEKYQNGCSSQRPSRQPSPVEQLAPIRSHSADFGRAAEMASGNSEEGKGMLLRNGDDRIRLPSPQRGTPDTSSTQGHPYTDQIVTINVSGMRFQTFESTLSRYPNSLLGDRNKRQHFFVSDTNEFFFDRHRTTSSSFTFEIRNYLFESILYIYQSGGRVKRPEIVPIDIFLKEMRFFQMGDDLLEEFWIAEGYEKPKEVMMPNNKTQRKIWELMEYPDSSLSARIIAFISIAVIALSIISFCWETVPSDIEEKPINNSATAELLDEMDEKHYSPFFWIELMCILWFTIELILRFISCPCKVTFATSVLNIIDFVAIAPFFVNFFFADTSKSNSSMSFAVLRVLRLVRVFRVFKLSRHSVGLQILGKTFRSSVQEFCLLIFFMAIALVLFASGMYFAEQGEPNSKFTSIPASFWFVLVTMTTVGYGDLVPLSPFGKVVGGMCAMIGVLTLALPVPIIVANFKHFYRQENRLASMKSKGDDADDDIA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in a variety of interneurons and sensory neurons; as well as body wall muscle.

DOI ID

10.1126/science.282.5396.2012; 10.1074/jbc.m605814200; 10.1113/jphysiol.2010.200683

RefSeq

NP_001022516.1 [Q8I4B0-5]; NP_001040829.1 [Q8I4B0-6]; NP_001254226.1; NP_496104.2 [Q8I4B0-4]; NP_871934.1 [Q8I4B0-2]; NP_871935.1 [Q8I4B0-1]; NP_871936.1 [Q8I4B0-3]